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GOT1 inhibitor-1
CAS No. 732973-87-4
GOT1 inhibitor-1 ( GOT1 inhibitor 2c )
产品货号. M24741 CAS No. 732973-87-4
GOT1抑制剂-1是一种新型、有效的非共价谷氨酸草酰乙酸转氨酶1 (GOT1)抑制剂，IC50为8.2 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1596 | 有现货 |
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| 10MG | ￥2657 | 有现货 |
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| 25MG | ￥4520 | 有现货 |
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| 50MG | ￥6383 | 有现货 |
|
| 100MG | ￥9072 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GOT1 inhibitor-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GOT1抑制剂-1是一种新型、有效的非共价谷氨酸草酰乙酸转氨酶1 (GOT1)抑制剂，IC50为8.2 uM。
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产品描述GOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
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体外实验PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research.In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM.
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体内实验——
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同义词GOT1 inhibitor 2c
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通路Others
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靶点Other Targets
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受体GOT1
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研究领域——
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适应症——
化学信息
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CAS Number732973-87-4
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分子量354.83
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分子式C19H19ClN4O
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纯度>98% (HPLC)
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溶解度DMSO:120mg/ml(338.19mM; need ultrasonic)
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SMILESO=C(Nc(cc1)ccc1Cl)N(CC1)CCN1c1c(cc[nH]2)c2ccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Anglin J , Zavareh R B , Sander P N , et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma[J]. Bioorganic & Medicinal Chemistry Letters, 2018:S0960894X18303743.
产品手册
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